Systemic effects of implanting photosynthetic biomaterial. Five days post-transplantation no significant differences were detected among the groups in the size of the immune organs (spleen and lymph nodes). The weight loss of the animals did not differ between the two groups. Quantification of immunoglobulins G (IgG) and M (IgM) did not show any variation between the control and SymbioDerm groups. Cytokines C5a, CCL1, CCL12, CD54, M-CSF and TIMP-1 were equally present in the serum of animals regardless the experimental group.